• Question: what has been your best scientific discovery to date in devolping cures for cancer?

    Asked by whmegandnath to Blanka on 4 Jul 2012.
    • Photo: Blanka Sengerova

      Blanka Sengerova answered on 4 Jul 2012:

      Good question. My work is a very small part of cancer research, but so far most importantly I have shown that a protein called SNM1a (it’s a nuclease, meaning it cuts DNA strands like moleculat scissors) is involved in the repai of interstrand crosslinks. Interstrand crosslinks connect two DNA strands within the doubke helix like glue and interstrand linkers are used as cancer therapeutics. It is then possible that stopping SNM1A working might be a useful combination therapy. Does that make sense or should I clarify more?